In recent years, the Marc Jacobs brand has increased the number of boutiques and direct point of service locations. This is evident in the signature list of cities featured in the company's print advertisements (although such adverts do not provide an entirely accurate or exhaustive survey of the brand's retail operations). Some of these branded showrooms present only a certain portion of the company's several brands (The Marc Jacobs Collection, Marc by Marc Jacobs, and Little Marc, a children's line) . A number of branded boutiques, for instance, feature only the Marc by Marc Jacobs product line. As of May 2008, Marc Jacobs boutiques in the United States include multiple locations in New York, San Francisco, and Los Angeles, as well as shops in Boston, Bal Harbour, Las Vegas, Guam, Chicago, Savannah, and Provincetown, Massachusetts. Worldwide, other such stand-alone stores are found in Europe (Paris, London, Madrid, Copenhagen and Moscow), the Middle East (Beirut, Riyadh, Dubai, Kuwait, and Doha), across Japan (multiple locations in Tokyo and Osaka, as well as Kyoto, Kobe, Nagoya, Sendai, Shizuoka, Nagano, Chiba, Matsuyama, and Tottori), Korea (multiple locations in Seoul) and elsewhere in Asia (multiple locations in Hong Kong and Taipei, as well as Shanghai, Beijing, Chengdu, Guangzhou, Manila, Kuala Lumpur, Singapore, Jakarta, and Bangkok). The various ready-to-wear and accessory collections are also widely available at leading department stores around the globe.

In February 2008, Jacobs was accused of plagiarism. It was revealed that a scarf from his collection had the exact same design as a scarf created in the 1950s by Swedish designer Gösta Olofsson, after Esquire writer Rob Millan discovered the scarf's use in a print ad and reported the allegation in the January 2008 issue. In early March, Göran Olofsson, the son of Gösta Olofsson, and Jacobs settled on the issue through monetary compensation. In 2009, Jacobs launched a shirt, sold at his stores, demanding the legalization of gay marriage. In February 2010, Jacobs sued Ed Hardy for infringing on the designs of one of his embroidered handbags.

In 2006 he started a new line of body splash fragrances in affordable huge 10 oz. bottles which are distributed by Coty. First only being sold in perfume boutiques, they have become more and more popular during the recent years.